Publications
2024
DE OLIVEIRA, R.M. ; Rocha, M.S. . Effects of the size and concentration of depleting agents on the stabilization of the double-helix structure and DNA condensation: A single molecule force spectroscopy study. CHEMICAL PHYSICS LETTERS, v. 836, p. 141037, 2024.
JOSHI, JOHA ; MCCAULEY, MICAH J. ; MORSE, MICHAEL ; MUCCIO, MICHAEL R. ; KANLONG, JOSEPH G. ; ROCHA, MÁRCIO S. ; ROUZINA, IOULIA ; MUSIER-FORSYTH, KARIN ; WILLIAMS, MARK C. . Mechanism of DNA Intercalation by Chloroquine Provides Insights into Toxicity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 25, p. 1410, 2024.
PORTILHO, E.A. ; ROSÁRIO, V.N. ; Rocha, M.S. . On the subtle competition between groove binding and intercalation of small drugs with deoxyribonucleic acid (DNA): The case of chloroquine. CHEMICAL PHYSICS LETTERS, v. 850, p. 141453, 2024.
2023
MOURA, T.A.; ANDRADE, U.M.S.; MENDES, J.B.S.; Rocha, M.S. Modulating the trapping and manipulation of semiconductor particles using Bessel beam optical tweezers. OPTICS AND LASERS IN ENGINEERING. Fator de Impacto(2022 JCR): 4,6000, v.170, p.107778 – , 2023.
ALTOÉ, LORENA SOUZA CASTRO; DE ARAÚJO COSTA, ETHE; TAVARES, GABRIELLA PETERLINI; ROCHA, MÁRCIO SANTOS; QUEIROZ, JOSÉ HUMBERTO DE; GONÇALVES, JULIANA BARBOSA COITINHO; DE FIGUEIREDO, SUELY GOMES; DE ARAÚJO, JACKSON VICTOR. On the interactions involving serine proteases obtained from Monacrosporium thaumasium (Ascomycota: Orbiliomycetes) and deoxyribonucleic acid (DNA): biological macromolecules in action. ARCHIVES OF MICROBIOLOGY. Fator de Impacto(2022 JCR): 2,8000, v.205, p.208 – , 2023.
OLIVEIRA, KAIRON M.; MOURA, TIAGO A.; LUCAS, JANAÍSA L. C.; TEIXEIRA, ALVARO V. N. C.; ROCHA, MÁRCIO S.; MENDES, JOAQUIM B. S. Use of Organic Semiconductors as Handles for Optical Tweezers Experiments: Trapping and Manipulating Polyaniline (PANI) Microparticles. Acs Applied Polymer Materials. , v.5, p.nd – , 2023.
2022
DE OLIVEIRA, RAYANE M. ; MOURA, TIAGO A. ; ROCHA, MÁRCIO S. . Caffeine Enhances the Toxicity of Platinum-Based Drugs at the Molecular Level Even Outside of the Intracellular Environment: A Single-Molecule Force Spectroscopy Study. JOURNAL OF PHYSICAL CHEMISTRY B, v. 126, p. 3291-3299, 2022.
COSTA, ETHE A. ; GONÇALVES, AMANDA P. ; BATISTA, JOSIANE A. D. ; BAZONI, RANIELLA F. ; SANTOS, ANÉSIA A. ; ROCHA, MÁRCIO S. . New Insights into the Mechanism of Action of the Drug Chloroquine: Direct Interaction with DNA and Cytotoxicity. JOURNAL OF PHYSICAL CHEMISTRY B, v. 126, p. 3512-3521, 2022.
ANDRADE, U.M.S. ; CASTRO, A.S.B. ; OLIVEIRA, P.H.F. ; DA SILVA, L.H.M. ; Rocha, M.S. . Imidazolium-based ionic liquids binding to DNA: Mechanical effects and thermodynamics of the interactions. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, v. 214, p. 500-511, 2022.
2021
ANDRADE, ULISSES ; GARCIA, ALOÍSIO ; ROCHA, MARCIO . A Bessel beam optical tweezers for manipulating superparamagneticbeads. APPLIED OPTICS, v. 60, p. 1, 2021.
MOURA, T.A. ; JUNIOR, R.L.R. ; Rocha, M.S. . Caffeine modulates the intercalation of drugs on DNA: A study at the single molecule level. BIOPHYSICAL CHEMISTRY, v. 277, p. 106653, 2021.
BAETA, JEFFERSON ; ANDRADE, ULISSES ; OLIVEIRA, RAYANE ; OLIVEIRA, LEANDRO ; SANTOS, ANÉSIA ; DIAZ-MUÑOZ, GASPAR ; ROCHA, MÁRCIO ; DIAZ, MARISA . Allyl Dibenzoylmethane Derivative: Antimelanoma Activity and Study of Its Molecular Mechanism of Interaction with DNA. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, v. 00, p. 1, 2021.
2020
BAZONI, R. F. ; MOURA, T. A. ; Rocha, M. S. . Hydroxychloroquine Exhibits a Strong Complex Interaction with DNA: Unraveling the Mechanism of Action. Journal of Physical Chemistry Letters, v. 11, p. 9528-9534, 2020.
SILVA, E. F.; ANDRADE, U. M. S.; DE OLIVEIRA, K. M.; TEIXEIRA, A. V. N. C.; Rocha, M. S.
Dodecyltrimethylammonium bromide surfactant effects on DNA: Unraveling the competition between electrostatic and hydrophobic interactions. PHYSICAL REVIEW E, v.102, p.032401 – , 2020.
BATISTA, J.A.D.; OLIVEIRA, L.; MOURA, T.A.; DOS ANJOS, V.C.; BELL, M.J.V.; Rocha, M.S.
On the use of Europium (Eu) for designing new metal-based anticancer drugs. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.531, p.1 – , 2020.
OLIVEIRA, L.; CAQUITO, J. M.; ROCHA, M. S.
Transplatin ineffectiveness against cancer from a molecular perspective: A single-molecule force-spectroscopy study. PHYSICAL REVIEW E, v.101, p.062412 – , 2020.
ALVES, P. S.; Mesquita, O. N.; ROCHA, M. S. Model for DNA Interactions with Proteins and Other Large Ligands: Extracting Physical Chemistry from Pure Mechanical Measurements. JOURNAL OF PHYSICAL CHEMISTRY B. , v.124, p.1020 – 1024, 2020.
MOURA, T. A.; ANDRADE, U. M. S.; MENDES, J. B. S.; ROCHA, M. S. Silicon microparticles as handles for optical tweezers experiments. OPTICS LETTERS. , v.45, p.1055 – , 2020.
2019
MOURA, T.A. ; OLIVEIRA, L. ; Rocha, M.S. . Effects of caffeine on the structure and conformation of DNA: A force spectroscopy study. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, v. 130, p. 1018-1024, 2019.
CAMPOS, W. H.; MOURA, T. A.; MARQUES, O. J. B. J.; FONSECA, J. M.; MOURA-MELO, W. A.; ROCHA, M. S.; MENDES, J. B. S. Germanium microparticles as optically induced oscillators in optical tweezers. Physical Review Research. , v.1, p.033119 – , 2019.
OLIVEIRA, L.; CAQUITO JUNIOR, J. M.; ROCHA, M. S. Oxaliplatin effects on the DNA molecule studied by force spectroscopy. BIOMEDICAL PHYSICS & ENGINEERING EXPRESS. , v.5, p.055009 – , 2019.
LIMA, C. H. M.; CAQUITO JUNIOR, J. M.; OLIVEIRA, R. M.; ROCHA, M. S. Pixantrone anticancer drug as a DNA ligand: Depicting the mechanism of action at single molecule level. EUROPEAN PHYSICAL JOURNAL E. , v.42, p.130 – , 2019.
2018
LIMA, C.H.M. ; ALMEIDA, G.O. ; Rocha, M.S. . A cooperative transition from the semi-flexible to the flexible regime of polymer elasticity: Mitoxantrone-induced DNA condensation. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1862, p. 1107-1114, 2018.
PUBLIO, B. C. ; MOURA, T. A. ; LIMA, C. H. M. ; ROCHA, M. S. . Biophysical characterization of the DNA interaction with the biogenic polyamine putrescine: A single molecule study. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, v. 112, p. 175-178, 2018.
CAMPOS, WARLLEY ; FONSECA, JAKSON M. ; DE CARVALHO, VAGNER E. ; MENDES, JOAQUIM B. S. ; ROCHA, MARCIO S. ; MOURA-MELO, WINDER A. . Topological insulator particles as optically induced oscillators: towards dynamical force measurements and optical rheology. ACS Photonics, v. 5, acsphotonics.7b01322, 2018.
NASCIMENTO, FERNANDA R. ; MOURA, TIAGO A. ; BAETA, JEFFERSON V.P.B. ; PUBLIO, BRUNO C. ; FERREIRA, POLLYANNA M.F. ; SANTOS, ANÉSIA A. ; FRANÇA, ANDRESSA A.P. ; ROCHA, MARCIO S. ; DIAZ-MUÑOZ, GASPAR ; DIAZ, MARISA A.N. . New antineoplastic agent based on a dibenzoylmethane derivative: Cytotoxic effect and direct interaction with DNA. BIOPHYSICAL
CHEMISTRY, v. 238, p. 1, 2018.
OLIVEIRA, L. ; CAQUITO, J.M. ; Rocha, M.S. . Carboplatin as an alternative to Cisplatin in
chemotherapies: New insights at single molecule level. BIOPHYSICAL CHEMISTRY, v. 241, p. 1,
2018.
CAMPOS, WARLLEY H. ; FONSECA, JAKSON M. ; MENDES, JOAQUIM B. S. ; ROCHA, MÁRCIO S. ;MOURA-MELO, WINDER A. How light absorption modifies the radiative force on a microparticle in optical tweezers. APPLIED OPTICS, v. 57, p. 7216, 2018.
OLIVEIRA, LEANDRO ; CAMPOS, WARLLEY ; ROCHA, MARCIO . Optical Trapping and Manipulation of Superparamagnetic Beads Using Annular-Shaped Beams. Methods and
Protocols, v. 1, p. 44, 2018.
DA SILVA, P.C.A. ; SANTOS, A.A. ; ALVES, S.G. ; Martins, M.L. . Cell aggregation in monolayer culture: Clues to a universal kinetics. PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS, v. 510, p. 725-740, 2018.
2017
ROCHA, MÁRCIO SANTOS; STORM, INGEBORG M. ; BAZONI, RANIELLA FALCHETTO ; RAMOS, ÉSIO BESSA ; HERNANDEZ-GARCIA, ARMANDO ; COHEN STUART, MARTIEN A. ; LEERMAKERS, FRANS ; DE VRIES, RENKO . Force and Scale Dependence of the Elasticity of Self-Assembled DNA Bottle Brushes. MACROMOLECULES, v. 51, acs.macromol.7b01795, 2017.
LIMA, C. H. M. ; DE PAULA, H. M. C. ; DA SILVA, L. H. M. ; Rocha, M. S. . Doxorubicin hinders DNA condensation promoted by the protein bovine serum albumin (BSA). BIOPOLYMERS, v. 107, p. e23071, 2017.
OLIVEIRA, L. ; Rocha, M. S. . Force spectroscopy unravels the role of ionic strength on DNA-cisplatin interaction: Modulating the binding parameters. PHYSICAL REVIEW E, v. 96, p. 032408, 2017.
ROCHA, J. C. B. ; SILVA, E. F. ; OLIVEIRA, M. F. ; SOUSA, F. B. ; TEIXEIRA, A. V. N. C. ; Rocha, M. S. . β -Cyclodextrin polymer binding to DNA: Modulating the physicochemical parameters. PHYSICAL REVIEW E, v. 95, p. 052416, 2017.
REIS, L. A. ; Rocha, M. S. . DNA interaction with DAPI fluorescent dye: Force spectroscopy decouples two different binding modes. Biopolymers (New York. Print), v. 107, p. 23015, 2017.
LIMA, C. H. M. ; Rocha, M. S. ; RAMOS, E. B. . Unfolding DNA condensates produced by DNA-like charged depletants: A force spectroscopy study. The Journal of Chemical Physics, v. 146, p. 054901, 2017.
SOUZA VILELA PODESTÁ, TATIANE ; VENZEL ROSEMBACH, TIAGO ; APARECIDA DOS SANTOS, ANÉSIA ; LOBATO MARTINS, MARCELO . Anomalous diffusion and q-Weibull velocity distributions in epithelial cell migration. PLoS One, v. 12, p. e0180777, 2017.
2016
BERNAL, WILSON ; SILVA, EDUARDO ; Rocha, Marcio Santos . Unraveling the physical chemistry and the mixed binding modes of complex DNA ligands by single molecule stretching experiments. RSC Advances: an international journal to further the chemical sciences, v. 6, p. 105631-105637 , 2016.
SILVA, E. F. ; BAZONI, R. F. ; RAMOS, E. B. ; ROCHA, M. S. . DNA-doxorubicin interaction: new insights and peculiarities. Biopolymers (New York. Print), v. 107, p. e22998, 2016.
CRISAFULI, F. A. P. ; DA SILVA, L. H. M. ; FERREIRA, G. M. D. ; RAMOS, E. B. ; Rocha, M. S. . Depletion interactions and modulation of DNA-intercalators binding: Opposite behavior of the -neutral- polymer poly(ethylene-glycol). Biopolymers (New York. Print), v. 105, p. 227-233, 2016.
2015
ALVES, P. S. ; Mesquita, O. N. ; Rocha, M. S. . Controlling Cooperativity in β-Cyclodextrin-DNA Binding Reactions. Journal of Physical Chemistry Letters, v. 6, p. 3549-3554, 2015.
ROCHA, M. S. Extracting physical chemistry from mechanics: a new approach to investigate DNA interactions with drugs and proteins in single molecule experiments. Integrative Biology, v. 7, p. 967-986, 2015.
BAZONI, R. F., LIMA, C. H. M., RAMOS, E. B., Rocha, M. S. Force-dependent persistence length of DNA-intercalator complexes measured in single molecule stretching experiments. Soft Matter, v.11, p.4306 – 4314, 2015
CRISAFULI, F. A. P., RAMOS, E. B., Rocha, M. S. Characterizing the interaction between DNA and GelRed fluorescent stain. European Biophysics Journal, v.44, p.1 – 7, 2015.
2014
SILVA, P. C. A. ; ROSEMBACH, T. V. ; SANTOS, A. A. ; Rocha, M. S. ; MARTINS, M. L. . Normal and Tumoral Melanocytes Exhibit q-Gaussian Random Search Patterns. Plos One, v. 9, p. e104253, 2014.
ROCHA, MARCIO S. ; CAVALCANTE, AGANOEL G. ; SILVA, ROBSON ; RAMOS, ESIO B. . On the Effects of Intercalators in DNA Condensation: A Force Spectroscopy and Gel Electrophoresis Study. Journal of Physical Chemistry. B, v. 118, p. 140410133725004, 2014.
2013
REIS, LUANA ; RAMOS, ESIO B. ; ROCHA, MARCIO S. . DNA Interaction With Diaminobenzidine Studied With Optical Tweezers and Dynamic Light Scattering. Journal of Physical Chemistry. B, v. 117, p. 131028163505004, 2013.
SILVA, EDUARDO F. ; RAMOS, ESIO B. ; ROCHA, MARCIO S. . DNA Interaction with Hoechst 33258: Stretching Experiments Decouple the Different Binding Modes. Journal of Physical Chemistry. B, v. 117, p. 130528105128000, 2013.
Cesconetto, E. C. ; Junior, F. S. A. ; Crisafuli, F. A. P. ; Mesquita, O. N. ; Ramos, E. B. ; Rocha, M. S. . DNA interaction with Actinomycin D: mechanical measurements reveal the details of the binding data. PCCP. Physical Chemistry Chemical Physics (Print). DOI:10.1039/C3CP50898F.
2012
SIMAN, L. ; Carrasco, I.S.S. ; SILVA, J. K. L. ; OLIVEIRA, M. C. ; Rocha, M. S. ; Mesquita, O. N. . Quantitative Assessment of the Interplay Between DNA Elasticity and Cooperative Binding of Ligands. Physical Review Letters (Print), v. 109, p. 248103, 2012.
Crisafuli, Fabiano ; Cesconetto, Estevan ; Ramos, Esio ; Rocha, Marcio Santos . DNA-Cisplatin interaction studied with single molecule stretching experiments. Integr. Biol., v. 2012, DOI: 10.1039/C2IB001, 2012.
Alves, P. S. ; Rocha, M. S. . Videomicroscopy calibration of optical tweezers by position autocorrelation function analysis. Applied Physics. B, Lasers and Optics (Print), v. 106, DOI: 10.1007/s00340, 2012.
Crisafuli, F. A. P. ; Cesconetto, E. C. ; Ramos, E. B. ; Rocha, M. S. . DNA-cisplatin binding mechanism peculiarities studied with single molecule stretching experiments. Applied Physics Letters, v. 100, p. 083701, 2012.
Carrasco, I.S.S. ; Bastos, F.M. ; Munford, M.L. ; Ramos, E.B. ; Rocha, M.S. . Atomic Force Microscopy of spermidine-induced DNA condensates on silicon surfaces. Materials Science & Engineering. C, Biomimetic Materials, Sensors and Systems (Print), v. 32, p. 36-39, 2012.
2011
Ramos, E. B. . Macromolecular crowding and the sizes of neutral flexible polymer chains: The role of colloids sizes and concentrations. Macromolecular Theory and Simulations, v. 20, p. 320-328, 2011.
2010
Rocha, M. S. . Revisiting the neighbor exclusion model and its applications. Biopolymers (New York. Print), v. 93, p. 1-7, 2010.
2009
Rocha, M. S. . Optical tweezers for undergraduates: Theoretical analysis and experiments. American Journal of Physics, v. 77, p. 704, 2009.
Rocha, M. S. . Modeling the entropic structural transition of DNA complexes formed with intercalating drugs. PHYSICAL BIOLOGY, v. 6, p. 036013, 2009.
Rocha, M. S. ; Lucio, A. D. ; Alexandre, S. S. ; Nunes, R. W. ; Mesquita, O. N. . DNA-psoralen: Single-molecule experiments and first principles calculations. Applied Physics Letters, v. 95, p. 253703, 2009